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The international 20vPnC study looks at how well this vaccine protects elderly adults against community-acquired pneumonia due to specific types of the disease-causing bacteria Streptococcus pneumoniae.

This study will evaluate the safety and efficacy of INCB123667 in participants with Platinum-Resistant Ovarian Cancer (PROC) with cyclin E1 overexpression.

Ocular assessments in patients treated with Tivdak in recurrent or metastatic cervical cancer.

The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemo-immunotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL).

This phase II trial tests the addition of venetoclax and/or blinatumomab to usual chemotherapy for treating infants with newly diagnosed acute lymphoblastic leukemia (ALL) with a KMT2A gene rearrangement (KMT2A-rearranged [R]) or without a KMT2A gene rearrange...

A phase III randomized trial for patients with de novo AML comparing standard therapy including gemtuzumab ozogamicin GO to CPX-351 with GO, and the addition of the FLT3 inhibitor gilteritinib for patients with FLT3 mutations.

This study wants to determine whether adding levocarnitine to standard care chemotherapy will reduce the chance of developing severe liver damage from asparaginase chemotherapy in ALL, LL, and/or MPAL patients.

The ACCLAIM-CTA study investigates how the medication lepodisiran affects the amount and type of plaque in the coronary blood vessels of adults who have high lipoprotein (a) (Lp(a)) levels.

The overall goal of this study is to see if selumetinib works just as well as the standard treatment of carboplatin and vincristine for patients with low-grade gliomas. Another goal of this study is to compare the effects of selumetinib versus carboplatin and ...

This phase II trial studies the best way to combine chemotherapy and radiation therapy based on how a patient responds to induction chemotherapy. It focuses on patients with localized non-germinomatous germ cell tumors (NGGCT) that haven't spread to other part...

The goal of ACT is to determine the optimal dose of alanyl-glutamine for first-time cases of uncomplicated C. difficile infection (CDI) in adults.

The Tapestry Study is researching an experimental treatment, AB-2004, that is designed to adsorb certain substances produced by bacteria in the gut to reduce their ability to enter the bloodstream and reach the brain. Scientific studies have shown there may be...

A phase III study evaluating active surveillance for low-risk germ cell tumors and comparing carboplatin versus cisplatin to find effective treatment with fewer side effects for standard-risk patients.

This study is for the treatment of intermediate and poor-risk germ cell tumors. These tumors are considered advanced, meaning they are harder to cure and may require more intense therapy to treat.

This study wants to compare progression-free survival (PFS) of a standard chemotherapy approach versus an immunotherapy approach in patients with newly diagnosed early stage classic Hodgkin lymphoma who have a rapid early response.

The international, randomized ALLAY-HFrEF study evaluates the safety and efficacy of a minimally invasive, no-implant interatrial shunt system in patients with heart failure.

The Alliance 072201 study compares the safety, side effects, and effectiveness of 2 monoclonal antibodies (relatlimab and nivolumab) with standard of care treatment (lomustine) in patients with recurrent glioblastoma.

The AlloNK cell therapy study evaluates whether a treatment combining healthy natural killer (NK) immune cells with the drug rituximab reduces the B cells involved in rheumatoid arthritis.

ALPINE looks at whether the new drug brepocitinib is safe and effective for the treatment of lichen planopilaris in adults.

This phase III trial compares the effect of giving triptorelin versus no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents.

This study is researching an investigational drug to see if it may delay relapse of Major Depressive Disorder (MDD) symptoms when taken alongside current antidepressant medication(s).

This trial compares 2 different surgical methods to evaluate if one has better outcomes for patients with osteosarcoma that has spread to the lung.