Trial Comparing Open vs. Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
A Phase III, Randomized Controlled Trial Comparing Open vs. Thoracoscopic Management of Pulmonary Metastases in Patients with Osteosarcoma
About
Protocol Description
Surgery for osteosarcoma that has spread to the lung is considered necessary for long-term survival. Open surgery has been the main approach. An alternative, minimally invasive approach called video-assisted thoracoscopic surgery (VATS) is also available.
COG# AOST2031
Eligibility Criteria
Inclusion Criteria
Diagnosis: Patients must have a histological diagnosis of osteosarcoma. Patients must have evidence of metastatic lung disease at the time of initial diagnosis, or at time of first recurrence following completion of therapy for initially localized disease. Patients must have ≤ 4 nodules per lung consistent with or suspicious for metastases; all nodules must be ≤ 3 cm size with at least one ≥ 3 mm.
Age: Patients must be < 50 years at the time of enrollment.
Exclusion Criteria
- Patients with unresectable primary tumor
- Patients with disease progression at either the primary or pulmonary metastatic site while on initial therapy
- Patients who received pulmonary surgery for lung metastasis prior to enrollment
See Protocol Section 3 for a complete comprehensive list of inclusion and exclusion criteria.
Primary Investigator
Dr. Glenn Edwards is the section chief of Pediatric Hematology/Oncology, as well as the Children's Oncology Group's principal investigator for Carilion Clinic. He has over 30 years of clinical experience and is board certified by the American Board of Pediatrics in Pediatrics and Pediatric Hematology/Oncology. He completed his fellowship at Walter Reed Army Medical Center and completed his internship and residency at Tripler Army Medical Center.
Contact Information
Wendy McCarty, C.C.R.P.
Clinical Research Coordinator II
