Markers and Predictors in Traumatic Brain Injury (TBI)
Traumatic brain injury (TBI) affects 5.3 million Americans and is a leading cause of death and disability. Inflammation is a key contributor to neuronal death post-injury; yet, relatively little progress has been made in relieving brain cell death after the initial incident.
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About
Protocol Description
In this study, we will determine the genetic profile of blood and examine whether particular protein is released in humans after TBI. The goal is to enroll 96 adults and 96 children in the study. Blood will be collected three times: within one day, two days and three days of being admitted to the hospital. Information will also be collected from the medical record and follow-up calls will be made to the participants to check on how the patient is doing long-term.
Eligibility Criteria
Inclusion Criteria
- Adults between 18-50 years old
- Children between 5-10 years old
- Patients presenting with moderate to severe concussive brain injury
Exclusion Criteria
- Children under 5 years old
- Adults over 50 years old
- Pregnant women (confirmed via pregnancy test in age-appropriate individuals that is ordered in trauma standard for TBI; this condition could bias results from patient samples)
- Hemoglobin <10 grams per deciliter/weight based
- Children whose one or both parents were involved in the same motor vehicle accident (MVA) as the child, who do not have the capacity to provide parental permission (two parents are required to provide parental permission for children to participate)
Primary Investigator
Eric Marvin, D.O., is a skull-base neurosurgeon who specializes in complex skull-base procedures, such as resection of tumors, carotid endarterectomy, craniotomies, awake surgery, neuro-mapping, stereotactic radiosurgery and emergency head and spine procedures. He has a variety of research interests aimed at helping improve his patients' lives and furthering understanding and treatment of skull-base procedures.
Contact Information
Jordan Darden, Ph.D.
Director of Neurosurgery Research
