Pericytes in Germinal Matrix Hemorrhage (GMH)
The aim of the present study is to determine whether altered levels of molecular signals involved in pericytes (helper cells called to stabilize new blood vessels) or other signals involved in maturing blood vessels relate to the underlying biological cause of brain bleeds that contribute to b...
About This Study
Summary
This study is investigating why some premature infants develop germinal matrix hemorrhage (GMH) and intraventricular hemorrhage (IVH), types of brain bleeds that can affect brain development. Researchers are studying biological signals that may help identify which infants are at higher risk and improve understanding of how these conditions develop.
The study will use umbilical cord blood that is routinely collected after birth for standard newborn care and would otherwise be discarded. Researchers may also analyze additional blood or cerebrospinal fluid samples that are collected as part of routine medical care if an infant develops a brain bleed. No extra procedures will be performed solely for this study.
By comparing samples from full-term and preterm infants, researchers hope to identify biological markers that could improve early detection, guide future treatments, and ultimately reduce the risk of brain injury in premature babies.
To be included in this study participants must be / have
- Patients aged 0 – 1
- Diagnosis of germinal matrix hemorrhage (GMH) grade I, II, III, or IV
- Diagnosis of intraventricular hemorrhage (IVH) of prematurity grade I, II, III, or IV
- Baby's mother aged 18 – 100
- All babies born live in CRMH
To be included in this study participants must not be / have
- Patients older than 1 year of age
- Diagnosis of meningitis or ventriculitis at the time of consent
For More About This Study or To Ask About Participation
Additional Information
Lead scientist at Carilion Clinic
Lisa Apfel, MD, has been practicing medicine since 2006. She received her medical degree, completed her internship and residency from the University at Buffalo. While she treats a variety of neurological conditions such as cancer and spinal disorders, her passion lies in pediatric neurosurgery. Dr. Apfel's clinical expertise includes spine surgery, brain tumor surgery, stereotactic and endoscopic cranial surgery, and pediatric neurosurgery. She has a variety of research interests that marry her interests in nutrition, pediatrics, and cancers.