Improved Diagnosis and Classification of Cervical Myelopathy
This prospective case-control study will assess the usefulness of magnetization transfer ratio (MTR) analysis in the evaluation and management of cervical spondylotic myelopathy (CSM). Consenting patients will have a magnetization transfer analysis protocol added to their standard of care MRI....
About
Protocol Description
This prospective case-control study will assess the usefulness of MTR analysis in the evaluation and management of cervical spondylotic myelopathy (CSM). Patients presenting with symptoms of cervical disease will be assessed using the standard Nurick and mJOA scales. Those demonstrating signs of CSM (Nurick grade 1-4 and/or mJOA 8-18) will have a magnetization transfer analysis protocol added to their standard of care MRI. The results of the MTR analysis will be compared to the mJOA and Nurick scores for each patient to determine the correlation.
Eligibility Criteria
Inclusion Criteria
- 21-85 years old
- Classic CSM symptoms (weakness, hyperreflexia, change in coordination)
- Classifying Nurick Grade and mJOA scores
Exclusion Criteria
- Conditions that preclude MRI analysis
- Comorbid neural disease (e.g. multiple sclerosis)
- Active peripheral or vascular neuropathy
Primary Investigator
Contact Information
Cara Spivey, M.S.
Clinical Research Coordinator
