HeadSMART II
Sometimes, initial diagnosis is inaccurate because CT scans look normal even though there is bleeding in the brain. The TBI test being developed by BRAINBox could become a standardized way to diagnose mTBI (mild traumatic brain injury) and improve patient...
About
The goal of HeadSMART II (HEAD injury Serum markers and Multi-modalities for Assessing Response to Trauma) is to develop the BRAINBox TBI test, an in-vitro diagnostic TBI test that will aid in the diagnosis and prognosis of patients with mild traumatic brain injury (mTBI) by incorporating blood biomarkers, clinical assessments and tools to measure associated neurocognitive impairments. This protocol proposes to collect data using a multi-modality approach to identify subjects with mTBI and their likelihood of chronic symptoms.
Eligibility Criteria
Inclusion Criteria
- Must be at least 18 years of age
- Ability to provide a blood sample within 96 hours of injury
- Ability to provide informed consent; consent may be obtained with assistance of a legally authorized representative (LAR)
- Must present to the Emergency Department (ED) or urgent care (UC) with a blunt head trauma
Exclusion Criteria
- Glasgow Coma Scale (GCS) score <13, as presented in ED at time of screening
- History of stroke with disabling outcomes
- Diagnosed dementia requiring assistance for daily living
- Any head trauma requiring medical attention from a physician within the last 6 months
- Received chemotherapy or radiation within the last year
Primary Investigator
Damon Kuehl, M.D.
Dr. Kuehl is the vice chair of Research in the Emergency Department at Carilion Clinic. His research includes broad interests in practice variation and how physicians make decisions and their implications in health care costs. For the past 5 years, he has developed multiple lines of inquiry around mTBI in collaboration with the Fralin Biomedical Research Institute at VTC and the Human Neuroimaging Lab at Virginia Tech and industry with a major goal to reduce guesswork in diagnosis and prognosis of TBI. His latest project is the new Carilion Brain Injury Center and the Roanoke Brain Injury Registry.
