Carilion Clinic Cardiology research spans the spectrum from large, multicenter randomized clinical trials to smaller studies conceived and conducted by cardiologists from Carilion Cardiovascular Institute.

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Structural Heart

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Our studies are sponsored by the National Institutes of Health, by device and pharmaceutical companies, by agencies such the American Heart Association and by foundations. Our overall goal is to participate in and conduct studies that will answer important questions in cardiovascular medicine.

Clinical Trials

This study investigates the use of the AccuCinch Ventricular Restoration System in patients who present with symptomatic heart failure that results in less blood being pumped out of the left ventricle with each contraction.
To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Repair System in patients with symptomatic severe tricuspid regurgitation who have been determined to be at an intermediate or greater estimated risk of mortality with tricuspid valve surgery by the cardiac surgeon with agreement by the local Heart Team.
This clinical trial is to demonstrate the safety and effectiveness of the Amplatzer Valvular Plug III (AVP III) as a treatment for clinically significant paravalvular leaks (PVL), a leak caused by a space left between natural heart tissue and the valve replacement from a previous surgical implant of a heart valve.
This study looks to establish the safety of mitral valve replacement through the femoral artery in the leg for patients that are not suitable for commercially available surgical or transcatheter treatment options.

Closed to Enrollment

This is an early feasibility study evaluation of a new technique and device that treats mitral valve leakage caused by damaged heart muscle in the left ventricle.
The ASAP-Too study is designed to establish the safety and effectiveness of the Watchman left atrial appendage closure device in subjects who are ineligible for oral anticoagulant therapy.
This study will evaluate the safety and effectiveness of the MitraClip System for the treatment of moderate-to-severe mitral regurgitation in symptomatic heart failure subjects who are not suitable for mitral valve surgery.
This is an early feasibility evaluation of the AccuCinch Ventricular Restoration System in patients with heart failure.
This is a multi-center early feasibility study of the AccuCinch Ventricular Restoration System in patients with prior mitral valve intervention and a mitral valve that does not close tightly, allowing blood to flow backward in the heart.
This study is for patients who have been diagnosed with severe aortic stenosis (calcium deposits and thickening of the valve leaflets) who are asymptomatic, not showing symptoms of the condition, such as fatigue and shortness of breath.
The purpose of this study is to perform laceration of the anterior mitral leaflet to prevent left ventricular outflow tract obstruction (LAMPOON) and transcatheter mitral valve replacement (TMVR) in patients who do not have an alternative option to treat their mitral valve failure, using heart valve devices designed to implant in the aortic valve position.

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Coronary Artery Disease

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Coronary artery disease is the narrowing or blockage of the coronary (heart) arteries. This condition is usually caused by atherosclerosis. Atherosclerosis is the buildup of cholesterol and fatty deposits (called plaques) inside the arteries.

The purpose of this study is to simultaneously address four potential advances in ST-elevation myocardial infarction (STEMI) care for patients at least 65 years old who require a procedure to open their narrowed blood vessel(s) in an effort to see if these advances can improve the outcome for these patients.
A study of the safety and effectiveness of the conform device (left atrial appendage closure device).
Utilization of a heart pump to support patients undergoing percutaneous coronary intervention, a minimally invasive procedure to open blocked coronary (heart) arteries.
This clinical trial is for women with non-obstructive heart disease showing symptoms of ischemia, who will receive either high-dose heart medications or regular-dose medications.

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Heart Failure

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Heart failure, sometimes known as congestive heart failure, occurs when your heart muscle doesn't pump blood as well as it should. Certain conditions, such as narrowed arteries in your heart (coronary artery disease) or high blood pressure, gradually leave your heart too weak or stiff to fill and pump efficiently.

This clinical trial is for heart failure patients with low iron levels.

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Humanitarian Use Devices

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A humanitarian use device (HUD) is a medical device intended to benefit patients in the treatment or diagnosis of a disease or condition. Because usage numbers are too small to study in a large clinical trial, they are approved by the FDA for use on a limited basis.

This HUD is indicated for use in the treatment of a mechanical tear of the heart wall greater than 2.75mm in diameter.
This device is used to close a hole in the heart muscle wall that separates the heart's lower chambers.