Summer 2013 eNewsletter

Summer 2013 eNewsletter

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Latest News from the Office of Sponsored Projects

Senior Director's Message

Paul Estabrooks, Ph.D.

This has been a really busy quarter punctuated with the 2013 Carilion Research Day and applications for the Carilion Research Acceleration Program (RAP). Research Day was really a lot of fun and had a lot of outstanding poster presentations and keynote talks by Drs. Rob Gourdie, Mike Kolodney, and Tom Kerkering. The solid basis of science would not have been possible without our record 64 abstract submissions and the nearly 200 students, residents, nurses, physicians, and research faculty that attended. The evaluations were really positive and also gave some good ideas for next year's event. We also had a great response to this year's call for proposals for possible RAP grants. We had 18 submissions and were able to fund nine of them. I've listed the successful submissions below and, as you can see, we were able to fund across the basic to implementation science spectrum.

I've also continued working with the Carilion Clinic Physician's Research Committee on issues related to recruitment. We have made good progress in adapting and updated our methods for identifying and engaging patients in research studies. For example, the IRB created a new recruitment policy for minimal risk studies that allows researchers different avenues for contacting and inviting patients to participate in studies. The feedback from investigators using this policy has been very positive and with the projects I have been involved in, we have managed to get quick helpful feedback from Julie Wimmer, who manages applications related to minimal risk studies, that makes the process a smooth and enjoyable one.

The Research Committee is continuing to focus on methods to help improve the culture for research at Carilion Clinic and to facilitate better recruitment for studies that have greater than minimal risk. One consistent message we are getting that will help these efforts is to make sure that the departments that will be touched by a research project are involved early and often. We recently updated our Office of Sponsored Projects research application to include a better description of planned research activities to better help investigators make sure they are connected to all the people and departments who can help them complete their work. While we know it is a little more paper work early on, our goal is to help investigators (and departments) avoid surprises down the road.

As always, please share your successes and challenges with us so we can keep moving towards building a strong foundation of Carilion Clinic research to go along with our high quality patient care and medical education standards!



RAP 9 Awards

Sameh Aziz, MD - Ultrasound and Sleep Apnea - $24,700

Anthony Baffoe-Bonnie, MD - Gram Negative Rod Registry - $17,000

Soheir Boshra, MD - Anticholinergic Burden and Cognition - $19,300

Alice Christaldi, RN - Bladder Management in Inpatient Rehab - $24,000

Sandy Fogel, MD - Post-op Pneumococcal Vaccine - $21,500

William Kolb, MD - PT Guidelines for Low Back Pain - $11,400

Kurtis Moyer, MD - Capsule Contraction After Breast Reconstruction - $24,600

Jayasimha Rao, PhD - Role of rahU Protein - $22,100

Umar Sofi, MD - Glycemic Control in COPD - $16,000

Office of Sponsored Projects (OSP) updated staff

Daniel Harrington, MD VP of Academic Affairs

Paul Estabrooks, PhD Senior Director of Research

Jeannie Perkins Director, Clinical Trials

Nancy Gentry Director, Clinical Research Finance

Michelle Rothrock Sponsored Projects Coordinator

Matthew Soukup Grant Management Administrator

Kristin Knight Basic Science Research Lab Manager

Beth Harber Intellectual Property & Research Assessments

OSP Clinical Research Coordinators/Nurses

Andrea Bidanset, BS Specialty Area: OSP Research

Dawn Bowles, RN, CCRP Specialty Area: Cardiology Research

Karen Buchanan, RN, BSN Specialty Area: Cardiology Research

Roye Evans, MS, RN, CCRC Specialty Area: Infectious Disease Research

Sarah Henderson, BS Specialty Area: GYN Oncology Research

Yvonne Hodgkins, BS, CCRP Specialty Area: OSP Research

John Kundzins, BS Specialty Area: Surgery Research

Wendy McCarty, CCRP Specialty Area: Pediatric Oncology Research

Donna Sanders, MS Specialty Area: Psychiatry Research

Dana Selvia, BA Gyn Oncology Data Entry Research Assistant

Charlene Viers, RN, BSN, CCRP Specialty Area: Medicine Research

Lisa Wilkerson Specialty Area: OSP Research

Vivian Wilson, RN, BSN Specialty Area: Cardiology Research

New Employees

Andrea Bidanset

Andrea joined OSP in July of 2013 as a Clinical Research Coordinator. She has a BA in Psychology from the College of William and Mary. She has worked in the field of clinical research for the past four years, with a focus in surgery and oncology. Prior to joining OSP, she was a Clinical Research Coordinator for Blue Ridge Cancer Care.

Roye Evans, R.N.

Roye joined the Office of Sponsored Projects in July of 2013 as a clinical research nurse for the Infectious Disease Department. Prior to joining OSP, she was employed as a Nursing Coordinator for Integrative Medicine at Atlantic Health Systems in New Jersey, where she worked to develop a research program for alternative and complementary medicine while supervising inpatient and outpatient Integrative medicine services. Roye has a BA from the University of Virginia and an MS from Tri State College in New York. She is a licensed acupuncturist and a Board Certified Holistic Nurse.

John Kundzins

John joined the Office of Sponsored Projects in July 2013 as a clinical research coordinator for the Surgery Department. He graduated from Duke University in 2010 with a BS in Biology. John has worked in research laboratories as an undergraduate and after graduation at the University of Virginia. He also assisted in the administration of clinical research studies while working at the Kidney Research Institute at the University of Washington.

Donna Sanders

Donna joined OSP in December 2012 as a clinical research coordinator. She has a BS from the University of North Carolina at Greensboro and an MS in Psychology from the University of Phoenix. She has worked in healthcare and higher education. Prior to joining OSP she was a senior enrollment counselor at the University of Phoenix.

Dana Selvia

Dana joined OSP in December 2012 as a clinical research assistant. She is a former teacher with five years experience in Oncology clinical research. Prior to joining OSP, she was the research regulatory coordinator for the Blumenthal Cancer Center in Charlotte, NC. She has a BA from Milligan College.

Vivian Wilson, R.N. Vivian joined OSP in May 2013, as a Clinical Research Coordinator in the Cardiac Department. She has a BSN from the University of New York in Plattsburg. She has worked in healthcare for 35 years. Her initial focus was Dialysis and Kidney Transplantation. She, together with Dr. Joseph Hayes, started the Kidney Transplant Program at CRMH from 1992-1997. For the past six years, Vivian has worked in Cardiac Research at the Roanoke Heart Institute PLC. Lisa Wilkerson

Lisa joined the Office of Sponsored Projects in August 2013 as a Research Study Coordinator I. She is currently working on her BS in Psychology at Liberty University. She has worked in healthcare for thirteen years with the last three and a half as a Research Study Coordinator.

Featured Researcher

Roger Glick is the Senior Emergency Management Consultant for Carilion Clinic. Roger's scope of work encompasses hospital evacuations, pediatric disasters, and a catch-all of what remains. Roger's research consists of how hospitals identify hazards and then mitigate, prepare, respond to, and recover from those emergencies.

The Emergency Management Department (EMD) is a department of one and is effective and successful due to coalitions and collaborations between Carilion and other facilities and organizations interested in working on Healthcare Emergency Preparedness projects. An example of interested research partners are Doug Bish, PhD an Assistant Professor of Industrial Engineering at Virginia Tech, and Alice Ackerman, MD, Chair of Pediatrics at Carilion Clinic and VTC School of Medicine.

EMD’s research is about protecting patients and healthcare staff/responders. Meaning, in the broadest sense: the work is about protecting 1) patients already in a hospital, 2) patients who come to the hospital because of an emergency or disaster, and 3) the community as a whole that relies on hospitals to provide critical healthcare infrastructure at all times but especially during times of disaster.

This research is patient-centered but generally does not directly involve patients. Because our research does not require direct involvement of patients, and the fact that our research is not “wet lab” based research, makes the work somewhat unique but it is important research and “good science”. The work follows scientific method, is hypotheses driven, and is ultimately reviewed and valued by other scientists through peer-review presentations. Two of the more frequent outcomes from the research are the creation of “products” – models and tools.

For example, through our work on hospital evacuations, we have created Optimization Models – models which “consider” many complex components to the disaster process and model different solutions in order to create the optimal solution with the available resources. The best solution can be defined differently – the quickest evacuation, the evacuation requiring the least amount of resources, the evacuation that causes the least risk to the patients, etc. Through this research, Roger has built similar models that optimize patient evacuations inside the hospital using different evacuation devices, and EMD is currently developing a model to explore the movement of a large number of pediatric patients – either into the healthcare system because of a community disaster impacting children, or because of an emergency at the Children’s Hospital which requires evacuating the children to other community resources.

An example of a tool that Roger’s research has developed is the Regional Pediatric Disaster Champion Curriculum. In certain emergency scenarios, the number of pediatric patients would overwhelm a Children’s Hospital; therefore, regional hospitals that would not normally accept and treat pediatric patients, would need to do so. The literature explained many of the issues (e.g. lack of interest, poor knowledge/competency level, rapid knowledge decay, cost of acquiring and keeping current pediatric supplies and equipment, etc.) but missing were “doable” recommendations on how a community could prepare. This work and its collaborators created voluntary, sustainable coalitions and created a curriculum that equipped and supported providers in their work. The evaluations of that work have exceeded our optimistic expectations and have now become the basis for additional work with coalitions.

Two things excite Roger about his particular research: 1) the multi-disciplinary collaboration, and 2) the importance of the work.

Due to the nature of Roger’s research, it is critically important to build effective coalitions and collaborations to do the work. Currently Roger works with senior faculty and researchers from Carilion Clinic, VTCSOM, VT Industrial Engineering, VAMC-Salem, Virginia Department of Health, and others. He is also working with Carilion Clinic residents, VTC medical students, VT graduate students, and JCHS undergraduate students. The interdisciplinary approach produces better and faster results now, and equips future researchers and leaders with the life and research skills they will need throughout their careers.

The importance of this work is undisputed. Roger stated, “We live in a world where, emergency preparedness and response needs to be evidence-based best practice too, rather than anecdotal and well intentioned, because many, many lives depend on it – because of terrorism, natural emergencies, critical infrastructure failures, pandemics, etc. Our work and research is to develop processes and tools that are “all-hazards” – transferable between specific disaster types.”

Roger is excited and optimistic about what the next five years will bring for his research, which he believes will grow both in scope, collaborations, peer-review presentation recognition, and external funding. Roger sees his role in part as needing to prioritize and focus Carilion’s research efforts to continue to bring critical acclaim and recognition to Carilion and our partners through dedicated care for our patients, fostering good health within our community, and continuing to expand Carilion’s research pillar.

Basic Laboratory News

It was an exciting year at the research laboratory for the Roanoke Valley Governor School (RVGS) students participating in Carilion’s Research Educational Program. This was the program’s first year and though there were some delays and setbacks, it was quite a successful year and we’ve enjoyed working with such bright, motivated students.

Many of the 12 students working in the lab have very successful presentations at local, regional and state science fairs. Ben and Emily went on to the state competition and won 3rd place in the Cellular and Molecular Biology category for their project entitled “The Effect of Antagomirs on Apoptosis in Pancreatic Cancer Cells”. Will and Samip were chosen to attend the International Science and Engineering Fair (ISEF) in Phoenix, Arizona with their project entitled “Targeted Delivery of Iron Oxide Nanoparticles for Use in Magnetic Hyperthermia Cancer Treatment”. Though they didn’t place, the judges praised their project as interesting and original. At this year’s Virginia Junior Academy of Science Research (VJAS) Symposium which was presented on the Virginia Tech Campus, Brooke won first place and received the Catsby Jones Award for her project entitled “Investigation of Antisense Gene Therapy as a Treatment for Osteogenesis Imperfecta”. Congratulations to Brooke! Sachith received an honorable mention at VJAS for his project entitled “Enhancement of Insulin Secretion through Nanoparticle-Mediated Reconstruction of the Lipid Bilayer”. The judges at the VJAS were quite complementary of the students from the Roanoke Governor School stating they were “better prepared” and “more polished presenters” than the other competing students.

We are excited to announce that the Carilion Research Educational Program has just accepted ten more students from RVGS. Mentoring opportunities are available for faculty members at Carilion who have an interest in research and would like to participate and in this program. Please contact Kristin Knight at 540-985-8013 for more information.

Clinical Research Coordinator/Nurse Corner Cutting Edge Research in Pediatric Oncology Available at Carilion Clinic

The Children’s Oncology Group (COG), a National Cancer Institute supported clinical trials group, is the world’s largest organization devoted exclusively to childhood and adolescent cancer research. The COG unites more than 8,000 experts in childhood cancer at more than 200 leading children’s hospitals, universities, and cancer centers across North America, Australia, New Zealand, and Europe in the fight against childhood cancer.

Carilion Clinic, along with the Pediatric Hematologist/Oncologists Dr. Mandy Atkinson and Dr. Glenn Edwards are members of COG. There are also several support members in other departments throughout Carilion, such as the Departments of Pathology, Radiology, Pharmacy, Surgery, Nursing Radiation Oncology, and the Office of Sponsored Projects.

Today, more than 90% of 13,500 children and adolescents diagnosed with cancer each year in the United States are cared for at Children’s Oncology Group member institutions. COG’s unparalleled collaborative efforts provide the information and support needed to answer important clinical questions in the fight against cancer.

The Children’s Oncology Group has nearly 100 active clinical trials open at any given time. These trials include front-line treatment for many types of childhood cancers, studies aimed at determining the underlying biology of these diseases, and trials involving new and emerging treatments, supportive care, and survivorship.

The Children’s Oncology Group research has turned children’s cancer from a virtually incurable disease 50 years ago to one with a combined 5-year survival rate of 80% today. Our goal is to cure all children and adolescents with cancer, reduce the short and long-term complications of cancer treatments, and determine the causes and find ways to prevent childhood cancer.

Submitted by Wendy McCarty, Clinical Research Coordinator

Jefferson College of Health Sciences News Archive

Update on the JCHS VOICE (Violence Can End) Program New Emergency Phones and Towers Now Available on the JCHS Campus at CRCH

New emergency phones and towers have been installed on the JCHS campus at Carilion Roanoke Community Hospital (CRCH) and are now available for use.

You can identify the emergency phones and towers by the bright blue lights located at the top of the boxes, which are available for use by anyone in need of assistance, including members of the College community, Carilion Clinic employees and the public. They are located at the parking lot beside the old Registrar's Office at 915 South Jefferson Street, the intersections of Reid Drive & Jefferson Street, Elm Avenue & Jefferson Street and the upper and lower entrances of the CRCH Parking Garage.

To operate the phones, a user pushes the red emergency call button which will send an alert to the Carilion Clinic Police Dispatch Center. The Center is monitored 24 hours a day, seven days a week. Dispatchers will receive a readout showing the location of the phone or tower where the emergency call is coming from. Users then will have two-way communication with the dispatcher who will respond to the emergency. Closed circuit cameras are mounted near each emergency phone and tower which is also monitored in the Dispatch Center. You can see photos of the new emergency phone towers on the JCHS campus.

The funding and installation of these new phones and cameras was coordinated by the JCHS VOICE (Violence Can End) Program in cooperation with the Carilion Clinic Police Department. A special thanks also goes out to the CRCH Engineering Department and the Carilion Clinic Technology Service Group for their assistance in installing this equipment.

Grant statement: This project was supported by grant # 2008-WA-AX-0005 awarded by the Violence Against Women Office, Office of Justice Programs, U.S. Department of Justice. Points of View in this document are those of the author and do not necessarily represent the official position or policies of the U.S. Department of Justice.

Carilion’s "Camp Too Sweet" to Continue

The Helmsley Charitable Trust grant will contribute to the mission of Carilion's Camp Too Sweet by providing life changing opportunities to children from all walks of life--with an emphasis on children from low-income families--with diabetes and their families, so they can attend camp with their peers and receive the highest quality of care and support for those at greatest risk.

The Helmsley Charitable Trust has granted approximately $24,000 each summer for three years offering 30 additional youths the opportunity to attend to receive diabetes management and education.

Camp Too Sweet is operated by and directed through the Carilion Clinic Diabetes Management Program which is recognized by the American Diabetes Association (ADA).

Camp Too Sweet has been in existence for over 20 years, and provides a five-day, four-night, safe, classic week of summer camp for children and teens who have Type 1 and Type 2 diabetes (95% of the campers have Type 1 diabetes.)

The week is filled with fun and adventure, while helping children accept diabetes as a part of daily living. The medical team monitors campers' diabetes care 24 hours a day. The medical team consists of approximately 12 paid full-time and eight part-time healthcare professionals, and an average of 15 unpaid volunteers.

Office of Sponsored Projects (OSP) Listserv Announcement

Carilion Clinic OSP distributes a list of new and current grant opportunities. This list includes new opportunities from federal agencies, as well as grant announcements from foundations and other organizations. Notices from federal agencies on e-submission, compliance or other subjects are also included in the e-mail.

If you are interested in subscribing to funding opportunities and announcement e-mail list, please e-mail with "subscribe to OSP listserv" in the subject line.

Roanoke Valley SoCRA Update

The local Roanoke Valley SoCRA Chapter was held on Wed 3/13/13 at CRMH.

Our guest speaker was Kristin Knight, MS, Manager of Carilion Clinic's Basic Science Research Lab located on the 4th floor at Carilion Roanoke Community Hospital.

Kristin shared with the group the capabilities of the lab, its vital role in research, and the research currently occurring in the lab. Our next meeting will be this fall.

Carilion Clinic Hosted the 6th Annual Research Day - 2013

The Office of Sponsored Projects (OSP) held its 6th annual Carilion Clinic Research Day on April 25, 2013, at the Virginia Tech Carilion School of Medicine (VTCSOM) with more than 140 clinicians and researchers attending.

This year’s event was privileged to engage three dynamic speakers:

“Novel Wound Healing Drugs”—Robert G. Gourdie, Ph.D. (Virginia Tech Carilion Research Institute and Carilion Clinic)

“Discovery and Development of a Drug to Treat Double Chins”—Michael S. Kolodney, M.D., Ph.D. (Dermatology Section Chief, Carilion Clinic and VTC School of Medicine)

“An Applied Academic Approach to the Fungal Meningitis Outbreak at CRMH”—Thomas M. Kerkering, M.D. (Section Head, Infectious Diseases, Carilion Clinic and VTC School of Medicine)

The event also showcased 47 research projects through poster presentations from Carilion and Virginia Tech faculty, medical residents, medical students, JCHS faculty and students, and area high school students. The day also included oral presentations, and an awards ceremony for outstanding research.

The following poster presentations received top honors at the event.

Poster winners Faculty:
  • 1st - Ellen M. Harvey, DNP, Carilion Clinic "A Comparison of Traditional and Simulation TeamSTEPPS® Training Methods on Nurse Performance Related to Failure-to-Rescue"
  • 2nd - Jianmin Su, PhD, Virginia Tech Carilion Research Institute "Contributions of VLDLR and LRP8 in the Establishment of Retinogeniculate Projections"
  • 3rd - Harry Dorn, PhD, Virginia Tech Carilion Research Institute "Radiolanthanides Encapsulated in Fullerenes: A New Radiopharmecutical Platform"
  • 1st - Caroline P. Siemer, PharmD, Carilion Clinic "Evaluation of the Use of Stress Ulcer Prophylaxis in a Trauma Population Across Transitions of Care"
  • 2nd - Agathoklis Konstantinidis, MD, Carilion Clinic "Use of NSQIP to Reduce Surgical Mortality: Implementation of Intensive Pre-operative Screening and Intervention"
  • 3rd - Geoffrey T. Jao, MD, Carilion Clinic "Non-invasive Assessment of the Left Ventricular End-diastolic Pressure Using Portable Ultrasound Measurements of the Right Internal Jugular Vein"
  • 1st - Jose M. Jimenez, PhD/MPH Candidate, Virginia Tech " Utilizing Statistical Process Control Charts and Highly-detailed Simulation for Biosurveillance in Intensive Care Units to Control Healthcare Associated Infections"
  • 1st - Nathaniel DeYoung, Salem Veterans Affairs Medical Center and Purdue University " Predictors of Successful Completion of Cardiac Rehabilitation Following a Cardiacvascular Event"
  • 2nd - Olivia M. Fitch, Virginia Tech Carilion Research Institute and Baylor College of Medicine " Role of Experience in Formation of Heterogeneous Plasticity Outcomes in two Pathways of Mouse V1 in Response to a Fixed Time Delay Conditioning Protocol"
  • 3rd - Jeeshan A. Faridi, Virginia Tech Carilion School of Medicine " Investigation of Airway Location as a Risk Factor for Endobronchial Fire with the use of Neodymium-doped Yttrium Aluminum Garnet (ND:YAG) Laser Photoresection in a Swine Model"

Download the 2013 Research Day Abstract Book

For more information about Research Day and the opportunities available for conducting research through Carilion, visit the OSP website by selecting Departments from top menu of the Intranet home page, then Office of Sponsored Projects or by calling 540-985-8510 (88510).