Research

Research

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CURRENT FUNDED RESEARCH

  • Popham DL. PI: Melville S, Schleupner CJ. Improved Decontamination of Clostridium difficile spores. Virginia Tech Carilion Research Institute Seed Grant, $35,000.
  • Schleupner CJ. A Phase 3, Multicenter, Randomized, Double-Blind, Controlled Study To Evaluate The Efficacy And Safety Of Peramivir Administered Intravenously In Addition To Standard Of Care Compared To Standard Of Care Alone In Adults And Adolescents Who Are Hospitalized Due To Serious Influenza. BioCryst. 2010 - ?
  • Popham D, Schleupner C, Melville S (2009 June): Improved decontamination of clostridium difficile spores. Virginia Tech Carilion Research Institute Seed Grant. $30,000.

CLINICAL FACULTY

Deborah D. Demicco, M.D.

Current Research:

  • Restriction of Ciprofloxacin: Study of antimicrobial resistance patterns and reduction in pharmacy budget:: Deborah Demicco, MD, Amanda Colquitt, Pharm.D, Sheri Ober, Pharm.D

Dorothy C. Garner, M.D.

Current funded peer-reviewed grants:

  • Functional Role of rahU (PA0122) Protein/or Gene in Various Clinical Isolates of Pseudomonas aeruginosa: Jayasimah Rao, Dottie C Garner and Thomas M. Kerkering
  • Garner, D. A Preliminary Study of Patients with Clostridium difficile to Identify Potential Factors Related to Management of Special Enteric Contact Isolation. TechLabs $8,000
  • Garner, D. “Guess Work" out of Medicine - Can Molecular Genetics Provide the Answer? - Investigation of the Clinical Role of Pseudomonas aeruginosa PA0122 Gene Expression. Carilion Research Accelerated Program, $17,392.

UNFUNDED RESEARCH

  • Resistance of clinical Isolates of Clostridium difficile to vancomycin and metronidazole: Dottie Garner, Dale Grgurich, Terry Nicholson.
  • Molecular epidemiology of multi-drug resistant Pseudomonas aeruginosa. Dottie Garner, Jayasimha Rao, Frances Philps.

Thomas M. Kerkering, M.D., FACP, FIDSA

Current peer-reviewed grants:

  • Development of nanoscale biosensor assays to detect and differentiate Staphylococcus aureus and Methicillin-Resistant S. aureus (Focus area: Infectious Diseases): Thomas J. Inzana1*, Thomas M. Kerkering2, James R. Heflin1, and Aloka B. Bandara1. 1Virginia Tech, 2Carilion Clinic. Principal Investigator Above grant was awarded funding from the Virginia Tech Carilion Research Institute in the amount of $30,000 for 6 months. Feb 15, 2009– August 15, 2009
  • Functional Role of rahU (PA0122) Protein/or Gene in Various Clinical Isolates of Pseudomonas aeruginosa: Jayasimah Rao, Dottie C Garner and Thomas M. Kerkering
  • Above grant was awarded funding through Carilion’s Research Accelerated Program (RAP), in the amount of $25, 000 with funding to be in January 2010.
  • Boyle S, Sriranganathan N, Kerkering T. Use of antisense therapeutics to kill intracellular bacterial pathogens. Virginia Tech Carilion Research Institute Seed Grant, $30,000.
  • Edgar K, Kerkering T, Rao J. Amorphous drug polymer nanoparticles for infectious disease treatment. Virginia Tech Carilion Research Institute Seed Grant. $30,000

Stephanie E. Nagy-Agren, M.D.

Current research:

  • VA Collaborative Study: Outcome of Veterans receiving influenza vaccination.
  • Roberts S, Myles, K, Nagy-Agren S, Smith J: Novel identification and characterization of the quasi- species variation during H1N1 Swine flu evolution in humans. VTCRI Award, $30,000.

Jean A. Smith, MD

Current Research:

  • Roberts S, Myles, K, Nagy-Agren S, Smith J: Novel identification and characterization of the quasi-species variation during H1N1 Swine flu evolution in humans. VTCRI Award, $30,000.

RESEARCH FACULTY

Jayasimha Rao, Ph.D.

VTC School of Medicine and Research Institute

Current funded research:

  • Rao, J. Prediction and validation of novel targets of RsmA in Pseudomonas aeruginosa. Carilion Research Accelerated Program, $16,902
  • Rao, J and Kulkarni, R. Prediction and validation of novel targets of RsmA in Pseudomonas aeruginosa. NIH. Submitted.
  • Rao, Prediction and validation of novel targets of RsmA in Pseudomonas aeruginosa. Commonwealth Health Research Board Concept Application. Submitted.
  • Inzana T and Rao, J. Efficacy of dendritic tricarboxylato amphiphiles to treat methicillin-resistant staphylococcus aureus in biofilms. Commonwealth Health Research Board Concept Application. Submitted.

Liwu Li, Ph.D.

Current peer-reviewed grants:

  • National Institute of Health 03/01/02-02/28/08
    R01-AI50089
    Regulation of signaling events in Septic leukocytes $1,200,000 direct cost
    PI: Liwu Li
  • National Institute of Health
    R01-AI064414 $1,250,000 direct cost
    Novel regulation and function of IRAK 03/01/05-02/28/10
    PI: Liwu Li
  • National Institute of Health
    1RO1DK078765-01A1 12/2007 – 11/2012
    Inflammatory regulation of lipid accumulation $250,000 annual direct cost in skeletal muscle with obesity. ~$2,000,000 total
    PI: Matthew Hulver
    CO-PI: Liwu Li
  • National Institute of Health 07/2008-07/2010
    Angiotensin II Receptor Blockade and $125,000 annual direct cost
    Adipose Tissue Inflammation in Obesity. ~$500,000 total
    PI: Kevin Devy
    CO-PI: Liwu Li
  • National Institute of Health
    Animal Model Research for Veterinarians 10/2005-09/2011
    PI: X.J. Meng
    >CO-PI: Liwu Li
    $774,197 total cost

X.J. Meng, M.D., Ph.D.

Current peer-reviewed grants:

  • USDA-Coordinated Agricultural Program (PRRS CAP-2). PI, $1,000,000. 11/01/2008 –10/31/2012. Title: Innovative approaches to develop a broadly protective vaccine against porcine reproductive and respiratory syndrome virus (PRRSV).
  • National Institutes of Health (R01 AI065546). PI, $1,561,797. 03/01/08 – 02/28/2012.Title: Mechanism of Hepatitis E Virus Replication and Pathogenesis.
  • National Institutes of Health (2 R01 AI050611-06). PI, $1,266,300. 03/01/08 – 02/28/2012.Title: A chicken model to study hepatitis E virus pathogenesis.
  • National Institutes of Health (1T32 RR021819). PI, $874,885. 10/01/06 – 9/30/2011. Title: Animal Model Research for Veterinarians.
  • National Institutes of Health (R56 AI065546). PI, $335,938. 05/01/06 – 04/30/2008. Title: Hepatitis E Virus Biology.
  • USDA-NRI Competitive Grant Programs (NRI 2003-02205). PI, $175,000. 02/01/04 -01/31/07. Title: Chimeric infectious DNA clones to study type 2 porcine circovirus replication and pathogenesis.
  • National Institutes of Health (NIH R01 AI50611). PI, $868,560. 6/15/2002 - 6/14/2007.Title: A chicken model to study hepatitis E virus pathogenesis.
  • USDA-NRI Competitive Grant Programs (NRI 35204-12531). PI, $125,000. 9/01/2002 -8/31/2005. Title: Serological and molecular epidemiology of avian hepatitis E virus, an emerging virus causing hepatitis-splenomegaly syndrome in chickens in the United States.

Biswarup Mukhopadhyay, Ph.D.

Current peer-reviewed grants:

  • Accelerated Biomethanation of Sequestered Carbon Dioxide and Paraffin in Coal Beds Department of Energy, Co-PI $337,000 (BM’s own share), 2 years, August 2006-June 2008
  • A novel coenzyme F420-dependent sulfite reductase from Methanocaldococcus jannaschii: a component of a primitive cell biosynthesis and detoxification system, NASA Astrobiology: Exobiology and Evolutionary Biology Program, PI, $595,153, 3 years, 2005-2008
  • Microbial Conversion of Sequestered Greenhouse Gases, Department of Energy, Co-PI $330,000 Department of Energy, 2 years, July 2005-June 2007 (extended until July 31, 2009)
  • Reduction of Non-CO2 Greenhouse Gas Emissions Through In Situ Bioconversion of Methane, Department of Energy, Co-PI $342,735.00, 2 years, July 2005-June 2007 (extended until July 31, 2009)

DESCRIPTION OF RESEARCH FACULTY’S AREAS OF INTEREST

Jayasimha Rao, Ph.D.

Dr. Rao is a faculty member in the Division of Infectious Diseases at the VTC School of Medicine and Research Institute. His role will be that of research advisor for the basic sciences for the Infectious Disease Fellows and Faculty. He teaches laboratory techniques, research design and development of training grants. He is located at OS-3, as described in the PIF. He has five peer reviewed articles in the last 3 years and is the active PI on one grant. His research interests are novel proteins in Pseudomonas as they relate to virulence, development of bio-film and potential vaccine and antibiotic targets. He also plans to set up, with Dr. Kerkering, an overseas program in Hyderbad, India for the study of Chandapura Virus.

Liwu Li, Ph.D.

Dr. Li is an adjunct faculty member in the Division of Infectious Disease and is a tenured Professor of Biology at Virginia Tech University (OS-4) in Blacksburg, VA. His role will be that of research advisor for the basic sciences for the Infectious Disease Fellows and Faculty. He will teach laboratory techniques, research design and develop training grants.. He has seventeen peer reviewed articles in the last 3 years and is the active PI/Co-PI on five current NIH grants. His research interests are the structure, function and products of genes associated with the inflammatory response.

X.J. Meng, M.D., Ph.D.

Dr. Meng is an adjunct faculty member in the Division of Infectious Diseases and is a tenured Professor at the Virginia-Maryland School of Veterinary Medicine located at Virginia Tech University, (OS-4) in Blacksburg, VA, 35 miles from H-1. His role will be that of research advisor for the basic sciences for the Infectious Disease Fellows and Faculty. He will teach laboratory techniques, research design and develop training grants.. He has forty-five peer reviewed articles and seven book chapters in the last 3 years and is the active PI/Co-PI on eight current grants. His research interests involve zoonoses particularly as they involve porcine and avian viruses.

Biswarup Mukhopadhyay, Ph.D.

Dr. Mukhopadhyay is an adjunct faculty member in the Division of Infectious Diseases and is an Assistant Professor at the Virginia Bioinformatics Institute located at Virginia Tech University, (OS-4) in Blacksburg, VA, 35 miles from H-1. His role will be that of research advisor for the basic sciences for the Infectious Disease Fellows and Faculty. He will teach laboratory techniques, research design and develop training grants.. He has seven peer reviewed articles in the last 3 years and is the active PI/Co-PI on three current grants. His research interests involve the molecular basis for Mycobacterium tuberculosis drug resistance. He will also be setting up, with Dr. Kerkering, an overseas program in Indonesia for the study of TB.